.Nature Medication, Released online: thirteen September 2024 doi:10.1038/ s41591-024-03261-7In the non-randomized phase 3b/4 DESTINY-Breast12 research, trastuzumab deruxtecan (T-DXd) procedure of clients with HER2+ state-of-the-art bosom cancer and active or stable brain metastases revealed constant intracranial activity as well as systemic effectiveness of T-DXd.